Overview
The OSP Global Sensitivity package (ospsuite.globalsensitivity) facilitates the implementation of one-at-a-time (OAT) and global sensitivity analyses (GSA) of physiologically based pharmacokinetic (PBPK) models built in the Open Systems Pharmacology Suite. The package evaluates the sensitivity of user-selected pharmacokinetic (PK) parameters, such as the maximal concentration (Cmax) and the area under the curve (AUC), for user-selected model output time profiles, with respect to user-selected model input parameters.
Installation
See the installation instructions.
Documentation
A detailed account of existing functions and articles on how to use them can be found on the dedicated website.
Code of conduct
Everyone interacting in the Open Systems Pharmacology community (codebases, issue trackers, chat rooms, mailing lists etc.) is expected to follow the Open Systems Pharmacology code of conduct.
Contribution
We encourage contribution to the Open Systems Pharmacology community. Before getting started please read the contribution guidelines.
If you are contributing code, please be familiar with the coding standards.
License
OSP Suite Global Sensitivity package is released under the GPLv2 License.
All trademarks within this document belong to their legitimate owners.
References
[1] Najjar A, Hamadeh A, Krause S, Schepky A, Edginton A. Global sensitivity analysis of Open Systems Pharmacology Suite physiologically based pharmacokinetic models. CPT Pharmacometrics Syst Pharmacol. 2024;13:2052-2067. doi: 10.1002/psp4.13256