Aciclovir Mean Model Report

Table of Contents

• 1 Sensitivity Analysis
  • 1.1 Sensitivity Analysis for Aciclovir
• 2 PK parameters
  • 2.1 PK parameters for Aciclovir
• 3 Time profiles and residual plots
  • 3.1 Time profiles and residual plots for Aciclovir

1 Sensitivity Analysis

1.1 Sensitivity Analysis for Aciclovir

Figure 1-1: Most sensitive parameters for AUC_tEnd of Aciclovir Plasma.

Figure 1-2: Most sensitive parameters for Total body clearance/F of Aciclovir Plasma.

Figure 1-3: Most sensitive parameters for Vss (plasma)/F of Aciclovir Plasma.

Figure 1-4: Most sensitive parameters for C_max of Aciclovir Plasma.

2 PK parameters

2.1 PK parameters for Aciclovir

Table 2-1: PK parameters for Aciclovir

Path	Parameter	Value	Unit
Aciclovir Plasma	AUC_tEnd	4064.12	µmol*min/l
Aciclovir Plasma	Total body clearance/F	4.02	ml/min/kg
Aciclovir Plasma	Vss (plasma)/F	777.83	ml/kg
Aciclovir Plasma	C_max	50.25	µmol/l

3 Time profiles and residual plots

3.1 Time profiles and residual plots for Aciclovir

Figure 3-1: Time profiles for Aciclovir. Time profiles are plotted in a linear scale.

Figure 3-2: Time profiles for Aciclovir. Time profiles are plotted in a logarithmic scale.