Reliable, powerful and easy-to-use modeling & simulation tools for pharmaceutical and other life-sciences applications. Qualified and accepted by the scientific community including academia, regulatory agencies and industry. Available free to everyone.
We are pleased to announce the BETA release of PK-Sim and MoBi Version 11 Update 1 which is now available for download.
We are pleased to announce the new release of the OSP Suite Version 11 which is now available for download.
The major update is the integration of the moderate CYP3A4 inhibitor fluconazole.
A generic framework for the physiologically-based pharmacokinetic platform qualification of PK-Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interactions.
Predictive Performance of Physiology-Based Pharmacokinetic Dose Estimates for Pediatric Trials.
This introduction video describes the very basic steps required to build a PBPK model with PK-Sim® using Morphine as an example.
This tutorial demonstrates how to build a simple PBPK model of ciprofloxacin. Learn how to optimize parameters based on observed PK and mass balance information following intravenous and oral administration.
This tutorial presents how to compare two simulations of the same molecule with respect to their input parameter values and quickly determine differences. Also learn how to determine which simulation parameter values may differ from the original building block used to create the simulation.
Using morphine as an example, learn how to build pediatric PBPK models. Starting with optimization of an adult PBPK model for morphine, learn to build individual children and populations of children and compare their PK results to adults.
This tutorial introduces the fundamental concepts of PBPK/PD modeling with a special focus on practical implementation in a typical PBPK model building workflow.
Spending too much time trying to locate a specific parameter? Favorites is a powerful feature to help you be more efficient. This tutorial teaches you all you need to know about them.
This tutorial presents a step-by- step guide on how to setup a fully mechanistic drug-drug interaction model in PK-Sim®.
This tutorial presents some advanced chart customization features using chart settings and templates. Chart templates can be saved and reused to streamline your modelling workflows in PK-Sim® and MoBi®.
Scientifically exciting for diabetes researchers. Technically exciting for everyone with PBPK models of glucose, insulin, and glucagon coupled through non-mechanistic PD as well as systems pharmacology PD models.
Growing list of scientific journal publications that relates to OSP or describes work with PK-Sim® or MoBi®. Add your own contributions and label them or others appropriately to further grow and structure this database.